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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
20.3
Human Site:
Y252
Identified Species:
37.22
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
Y252
S
E
F
V
N
Q
P
Y
L
L
Y
S
V
H
M
Chimpanzee
Pan troglodytes
XP_522169
734
81883
L291
N
P
G
N
C
S
C
L
T
F
L
I
K
E
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
L303
N
P
G
N
C
S
C
L
T
F
L
I
K
E
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
Y252
T
E
F
V
N
Q
P
Y
L
L
Y
S
V
H
V
Rat
Rattus norvegicus
P19686
690
77548
Y251
T
E
F
V
N
Q
P
Y
L
L
Y
S
V
H
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
Y252
S
E
F
V
N
Q
P
Y
L
L
Y
S
V
Q
V
Chicken
Gallus gallus
XP_420375
688
77848
Y250
T
E
F
V
N
Q
P
Y
L
L
Y
S
I
Q
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
V234
C
F
N
P
D
P
T
V
G
V
A
M
P
G
L
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
S258
L
Q
S
S
P
Q
P
S
L
L
Y
T
V
V
V
Fruit Fly
Dros. melanogaster
Q07093
676
75644
P245
T
S
V
S
K
T
I
P
E
T
V
Q
R
S
N
Honey Bee
Apis mellifera
NP_001011650
699
78655
V261
E
L
Y
S
E
H
L
V
V
P
E
I
E
D
N
Nematode Worm
Caenorhab. elegans
O02298
688
78384
D262
R
Q
E
T
R
V
T
D
L
L
E
L
V
H
P
Sea Urchin
Strong. purpuratus
P16065
1125
126238
P496
E
P
P
L
D
M
P
P
C
G
F
H
G
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
0
N.A.
0
N.A.
86.6
86.6
N.A.
86.6
73.3
N.A.
0
40
0
0
26.6
6.6
P-Site Similarity:
100
6.6
N.A.
6.6
N.A.
100
100
N.A.
93.3
93.3
N.A.
20
60
6.6
13.3
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
8
0
0
0
16
0
16
0
8
0
0
0
0
0
16
% C
% Asp:
0
0
0
0
16
0
0
8
0
0
0
0
0
8
0
% D
% Glu:
16
39
8
0
8
0
0
0
8
0
16
0
8
24
0
% E
% Phe:
0
8
39
0
0
0
0
0
0
16
8
0
0
0
0
% F
% Gly:
0
0
16
0
0
0
0
0
8
8
0
0
8
8
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
8
0
31
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
24
8
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
0
16
0
0
% K
% Leu:
8
8
0
8
0
0
8
16
54
54
16
8
0
0
16
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
8
% M
% Asn:
16
0
8
16
39
0
0
0
0
0
0
0
0
0
16
% N
% Pro:
0
24
8
8
8
8
54
16
0
8
0
0
8
0
8
% P
% Gln:
0
16
0
0
0
47
0
0
0
0
0
8
0
16
0
% Q
% Arg:
8
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
16
8
8
24
0
16
0
8
0
0
0
39
0
8
0
% S
% Thr:
31
0
0
8
0
8
16
0
16
8
0
8
0
0
0
% T
% Val:
0
0
8
39
0
8
0
16
8
8
8
0
47
8
39
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
39
0
0
47
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _